Our research is situated at the intersection of fluid dynamics and computation with an emphasis on engineering and healthcare applications. In particular, we focus on developing state-of-the-art computational methods that leverage mathematical models and numerical simulations to improve understanding of biological and physiological flows. Our research is driven by the quests to answer questions from both fundamental fluid dynamics problems and practical applications. Our current research involves computational fluid dynamics (CFD), immersed boundary method, high-performance computing, biological fluid dynamics in nature, and biomedical flow in human respiratory system.