© Chengyu Li

Human Nasal Airflow

Computational Investigation of Nasal Symptoms

Nasal sinus disease is one of the most common medical conditions, affecting an estimated 30 million adults in U.S. with an annual health expenditure of $5.8 billion. In this project, CT-based CFD modeling techniques are used to provide a quantitative evaluation of the nasal pathology for individual patients.

Empty Nose Syndrome

Empty nose syndrome (ENS) is a rare but debilitating clinical syndrome that typically occurs after surgical therapy. The most common symptom is a paradoxical sensation of nasal obstruction, despite an open nasal airway. ENS patients also suffer from varying degrees of nasal crusting, dryness, nasal discharge, and facial pain. In this project, the CFD simulations are applied to explore the etiology of ENS from a fluid dynamics perspective.

Nasal Septal Perforation

Nasal septal perforation (NSP) may occur due to previous surgery, trauma, inflammatory disease, and nasal spray utilization. Symptoms accompanying NSP include whistling, crusting, epistaxis, nasal obstruction, and postnasal drip. This project aims to analyze the flow disturbance and wall shear stress (WSS) distribution around NSP margins for the patients with large NSPs (>2 cm).

Effect of Nasal Structural Features on Olfactory Sensitivity

Nasal airflow that effectively transports ambient odors to the olfactory receptors is important for human olfaction. Yet, the impact of nasal anatomical variations on the airflow pattern and olfactory function is not fully understood. Our study revealed a potential impact of normal variation in nasal structure and aerodynamic on normative variations in olfactory sensitivity.